Yes you can make exclusions in bulk by going to the Ad Sets tab and clicking on the Edit button next to one of the ad sets. After that, on the bar on the right side, you'll see the "Bulk Edit" option. 

When you click on the "Bulk Edit" button, a new pop-up will appear where you can make changes tot he ad sets in bulk. 

After making all the necessary changes, you need to click on the "Apply Changes" button and then click on the "Save & Quit" button on the main pop-up.

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